About MacuRest
About MacuRest
The Gap We Set Out to Fill
MacuRest was created by Dr. Louis Michaelos, a practicing ophthalmologist who spent years recommending AREDS2 supplements to patients with macular degeneration — and noticing something no supplement company had addressed.
The AREDS2 formula is validated. The National Eye Institute's landmark clinical trial showed it reduces AMD progression risk by approximately 25% in the appropriate patient population. That evidence is unambiguous, and every ophthalmologist who treats AMD relies on it.
But the formula was designed around daytime oxidative protection. Lutein and zeaxanthin filter blue light. Vitamins C and E neutralize free radicals from light exposure. Zinc supports retinal enzyme function. Every one of these mechanisms is relevant to what happens to your retina during the day.
What no supplement addressed was what happens at night.
The Overnight Problem
During sleep, the retinal pigment epithelium performs its most intensive maintenance work: breaking down and replacing worn photoreceptor outer segments in a process called phagocytosis. This overnight repair cycle is one of the most metabolically active processes in the human body, and it is progressively impaired in age-related macular degeneration.
Meanwhile, research on melatonin and ocular health was accumulating. The retina produces its own melatonin. AMD patients have lower melatonin levels than age-matched controls. A 2024 study in JAMA Ophthalmology found melatonin users had significantly lower AMD progression rates across 100,000+ patients. Melatonin plays a direct role in initiating the overnight repair cycle. And not a single AREDS2 supplement on the market was formulated with this overnight window in mind.
The Formula
MacuRest combines the complete AREDS2-inspired formula — lutein 10mg, zeaxanthin 2mg, vitamins C and E at clinical doses, zinc 25mg, and copper 2mg — with melatonin 5mg and B-complex vitamins. It is taken each evening with dinner, when fat-soluble nutrients absorb best, and when melatonin aligns with the body's natural circadian rhythm.
It is not a reinvention of AREDS2. It is the AREDS2 formula, taken at the right time, with the additional support the overnight repair window calls for.
About Dr. Louis Michaelos, D.O.
Dr. Louis Michaelos, D.O.
Board-Certified Ophthalmologist · Cornea & Refractive Surgery Specialist · Founder, MacuRest
- Doctor of Osteopathic Medicine (D.O.) — Nova Southeastern University
- Cornea & Refractive Surgery Fellowship — UNC Chapel Hill
- B.S. — Stetson University
- Third-generation ophthalmologist with 20+ years of clinical experience
- Practicing at St. Michael's Eye & Laser Institute, Largo, Florida
- Specializes in cornea, macular disease, and refractive surgery
The Clinical Research Behind MacuRest
MacuRest's formulation is grounded in peer-reviewed research from leading journals. Key references:
- Heng JS et al. (2024). Melatonin Use and Age-Related Macular Degeneration. JAMA Ophthalmology. — 100,000+ patient study showing melatonin users had significantly lower AMD progression rates.
- AREDS2 Research Group (2013). Lutein/Zeaxanthin for AMD. JAMA. — The landmark NEI trial establishing the AREDS2 formula.
- Feher J et al. (2005). Melatonin in AMD patients. Annals of the New York Academy of Sciences. — 100 AMD patients treated with nightly melatonin showed preserved visual acuity.
- American Academy of Ophthalmology (2024). AMD Treatment Guidelines.
Our Quality Commitment
🏭 GMP-Compliant Manufacturing
Produced in an FDA-registered, GMP-certified facility in the United States.
🌿 Non-GMO Formula
No genetically modified ingredients. No artificial colors, flavors, or beta-carotene.
🔬 Clinically Referenced Ingredients
Every ingredient chosen based on published peer-reviewed research, not marketing trends.
💊 Safe for Smokers
Beta-carotene free. Safe for current and former smokers per AREDS2 guidelines.
Our Guarantee
30-Day Money-Back Guarantee
If you're not satisfied with MacuRest for any reason within 30 days of purchase, contact us at support@macurest.com for a full refund — no questions asked. We stand behind the science and the product.
Learn more: How MacuRest works | Why evening dosing matters | Should I take AREDS2? (Quiz) | Frequently asked questions